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Study Of Effects Of Human Growth Hormone Replacement On Body Composition



In addition to studies conducted on AIDS positive patients, there have continued to be a number of studies conducted on the effects of human growth hormone therapy or other medical issues as well.

The Research Centre for Endocrinology and Metabolism at the University Hospital in Goteborg Sweden conducted a study over a one year time period in which a group of 118 adults, consisting of 70 men and 48 women with an average age of 49 years old were tested for the effects of growth hormone replacement on body composition, bone mass and metabolism after five years of treatment. Initially, in this study the participants were given a dose of 0.98 mg per day. That dosage gradually began to be lowered and after five years, the average daily dose was only 0.48 mg per day. The study indicated that the IGF-a score increased from -1.73 to 1.66 at the conclusion of the study. Furthermore, there was a sustained increase in lean body mass and a decrease in body fat. Overall, the human growth hormone treatment increased total body bone mineral content as well as lumbar and femur neck bone mineral contents.

In addition to the numerous benefits already mentioned, the study showed that total cholesterol and low density lipoprotein cholesterol were also decreased. Triglycerides and hemoglobin A were reduced at the conclusion of the study. The study also indicated that that the treatment was proven to be safe and well tolerated in the 118 adult participants tested. Generally, the effects on body composition and low density lipoprotein cholesterol were not seen until at least one year after treatment and other benefits such as the effects on bone mass, triglycerides and hemoglobin A were not experienced until more than one year after the onset of treatment. 10

The effects of human growth hormone treatment have also been tested on cardiac function as well as body composition and glucose metabolism. In a study conducted at the Department of Medical Sciences, University Hospital , Uppsala , Sweden , 53 adults between the ages of 18 and 78 were tested over a period of three months to ascertain the safety and effects of a fixed low dose of growth hormone. After the end of three months, the insulin-like growth factor otherwise known as IGF-1 as well as lipoprotein and lean body mass were increased. Total cholesterol levels and fat mass were reduced at the same time and there was also an increase in the glucose value of the individuals participating in the study.

This particular study showed that there were few side effects and that the side effects which were observed were mild. The researchers conducting the study concluded from the results that a fixed low-dose of human growth hormone resulted in improvements in body composition and lipid profile, without serious side effects and that there was subsequently a valid method to implement human growth hormone replacement in adults. 11

Research indicates that it is possible that human growth hormone treatments may be the answer to treating a number of illnesses and diseases that plague most of the world’s population. Crohn’s Disease, which is a disorder that affects the digestive tract and results in persistent diarrhea as well as abdominal pain, was recently the subject of a human growth hormone study. Crohn’s disease eventually causes bleeding and the breakdown of the intestinal wall and has no known cure, although researchers are always looking for ways in which the severe symptoms can be eased in patients who suffer from the disease.